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Article

Role of folate-homocysteine pathway gene polymorphisms and nutritional cofactors in Down syndrome: A triad study.

Human reproduction (Oxford, England) - 1 Aug 2015

Sukla K K, Jaiswal S K, Rai A K, Mishra O P, Gupta V, Kumar A, Raman R

Abstract excerpt

STUDY QUESTION: Do gene-gene and gene-environment interactions in folate-homocysteine (Hcy) pathway have a predisposing role for Down syndrome (DS)? SUMMARY ANSWER: The study provides evidence that in addition to advanced age, maternal genotype, micronutrient deficiency and elevated Hcy levels, individually and in combination, are risk factors for Down syndrome. WHAT IS KNOWN ALREADY: Polymorphisms in certain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26040482
DOI: 10.1093/humrep/dev126

Genes

MTHFR

Variants

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