Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China.

Journal of Zhejiang University. Science. B - 1 Feb 2008

Wang Shao-shuai, Qiao Fu-yuan, Feng Ling, Lv Juan-juan

Abstract excerpt

OBJECTIVE: To explore the relationship between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), the central enzymes in folate metabolism that affects DNA methylation and synthesis, and the risk of Down syndrome in China. METHODS: Genomic DNA was isolated from the peripheral lymphocytes of 64 mothers of children with Down syndrome and 70 age matched...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to China
Share to Down Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferredoxin-NADP Reductase

Share to Folic Acid

Share to Homozygote

Share to Lymphocytes

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Source

Open in PubMed Open full text

Identifiers

PMID: 18257130
DOI: 10.1631/jzus.B0710599
PMCID: PMC2225490

Genes

MTHFR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China.PMID 18257130Read ↗

Genetic polymorphisms involved in folate metabolism and maternal risk for down syndrome: a meta-analysis.Semantic proximity Read ↗

Maternal gene polymorphisms involved in folate metabolism as risk factors for Down syndrome offspring in Southern Brazil.Semantic proximity Read ↗

Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil.Semantic proximity Read ↗

Maternal methylenetetrahydrofolate reductase C677T polymorphism and down syndrome risk: a meta-analysis from 34 studies.Semantic proximity Read ↗

Functional variant in methionine synthase reductase decreases the risk of Down syndrome in China.Semantic proximity Read ↗

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome.Semantic proximity Read ↗

Screening of six polymorphisms related with folate metabolism in parents of individuals with Down syndrome.Semantic proximity Read ↗

MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndromeSemantic proximity Read ↗

Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China.Semantic proximity Read ↗

Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for Down syndrome offspring: a meta-analysis.Semantic proximity Read ↗

Maternal gene polymorphisms involved in folate metabolism and the risk of having a Down syndrome offspring: a meta-analysis.Semantic proximity Read ↗

Polymorphisms in genes RFC-1/CBS as maternal risk factors for Down syndrome in China.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.