Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring.

Neuroscience letters - 2 Jan 2009

Coppedè Fabio, Migheli Francesca, Bargagna Stefania, Siciliano Gabriele, Antonucci Ivana, Stuppia Liborio, Palka Giandomenico, Migliore Lucia

Abstract excerpt

We analyzed the role of six common polymorphisms in folate metabolizing genes as possible risk factors for having a child with Down syndrome (DS) in 94 Italian mothers of a DS child (MDS) and 113 matched control mothers, both aged less than 35 years at conception. Investigated polymorphisms include methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C, methionine synthase (MTR) 2756A>G, methionine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Chromosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down Syndrome

Share to Ferredoxin-NADP Reductase

Share to Folic Acid

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Micronuclei, Chromosome-Defective

Share to Mother-Child Relations

Source

Identifiers

PMID: 18983896
DOI: 10.1016/j.neulet.2008.10.074

Genes

MTHFR
MTR
TYMS
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring.PMID 18983896Read ↗

MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndromeSemantic proximity Read ↗

The impact of folate pathway polymorphisms combined to nutritional deficiency as a maternal predisposition factor for Down syndrome.Semantic proximity Read ↗

Maternal gene polymorphisms involved in folate metabolism and the risk of having a Down syndrome offspring: a meta-analysis.Semantic proximity Read ↗

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome.Semantic proximity Read ↗

MTHFR C677T and A1298C polymorphisms are risk factors for Down's syndrome in Indian mothers.Semantic proximity Read ↗

Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil.Semantic proximity Read ↗

The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defectsSemantic proximity Read ↗

Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.Semantic proximity Read ↗

Investigation of CBS, MTR, RFC-1 and TC polymorphisms as maternal risk factors for Down syndrome.Semantic proximity Read ↗

Maternal methylenetetrahydrofolate reductase C677T polymorphism and down syndrome risk: a meta-analysis from 34 studies.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase enzyme polymorphisms as maternal risk for Down syndrome among Turkish women.Semantic proximity Read ↗

Folate gene polymorphisms and the risk of Down syndrome pregnancies in young Italian women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.