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Article

The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease.

Human molecular genetics - 15 Dec 2014

Bonomo Jason A, Guan Meijian, Ng Maggie C Y, Palmer Nicholette D, Hicks Pamela J, Keaton Jacob M, Lea Janice P, Langefeld Carl D, Freedman Barry I, Bowden Donald W

Abstract excerpt

Familial clustering and presumed genetic risk for type 2 diabetic (T2D) and non-diabetic end-stage kidney disease (ESKD) appear strong in African Americans. Examination of exome sequencing data in African American T2D-ESKD cases and non-diabetic non-nephropathy controls identified two low-frequency variants in the RREB1 gene, a repressor of the angiotensinogen (AGT) gene previously associated with kidney...

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Source

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Identifiers

PMID: 25027322
DOI: 10.1093/hmg/ddu362
PMCID: PMC4240197

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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