Article
Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy.
Diabetes - 1 Apr 2008
Keene Keith L, Mychaleckyj Josyf C, Smith Shelly G, Leak Tennille S, Perlegas Peter S, Langefeld Carl D, Freedman Barry I, Rich Stephen S, Bowden Donald W, Sale Michèle M
Abstract excerpt
OBJECTIVE: Variants in the ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) gene have shown positive associations with diabetes and related phenotypes, including insulin resistance, metabolic syndrome, and type 1 diabetic nephropathy. Additionally, evidence for linkage for type 2 diabetes in African Americans was observed at 6q24-27, with the proximal edge of the peak encompassing the ENPP1 gene. Our...
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