Article
Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA.
Human genetics - 1 Aug 2010
Bostrom Meredith A, Lu Lingyi, Chou Jeff, Hicks Pamela J, Xu Jianzhao, Langefeld Carl D, Bowden Donald W, Freedman Barry I
Abstract excerpt
African Americans have increased susceptibility to non-diabetic (non-DM) forms of end-stage renal disease (ESRD) and extensive evidence supports a genetic contribution. A genome-wide association study (GWAS) using pooled DNA was performed in 1,000 African Americans to detect associated genes. DNA from 500 non-DM ESRD cases and 500 non-nephropathy controls was quantified using gel electrophoresis and...
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