Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of lymphokine-activated killer activity in T-replete and T-cell-depleted human bone marrow by interleukin 4.

Experimental hematology - 1 Oct 1991

Drobyski W R, LeFever A V, Truitt R L

Abstract excerpt

Donor-derived lymphokine-activated killer (LAK) cells appear to play a role in mediating an antileukemia effect in recipients of both T-replete and T-cell-depleted (TCD) bone marrow transplants. LAK activity, however, is subject to regulation by cytokines other than interleukin 2 (IL-2). The purpose of this study was to examine the effect of interleukin 4 (IL-4) on the induction of LAK activity in both T-replete...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Cell Adhesion
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-2

Share to Lymphocyte Activation

Share to Phenotype

Share to Receptors, Antigen, T-Cell

Share to Recombinant Proteins

Source

Identifiers

PMID: 1716592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of lymphokine-activated killer activity in T-replete and T-cell-depleted human bone marrow by interleukin 4.PMID 1716592Read ↗

Cytolytic function of clonable T cells after human bone marrow transplantation.Semantic proximity Read ↗

rIL-4 differentially regulates rIL-2-induced murine NK and LAK killing in CD8+ and CD8- precursor cell subsets.Semantic proximity Read ↗

Lymphokine-activated killer (LAK) precursor cell activity is present in infused peripheral blood stem cells and in the blood after autologous peripheral blood stem cell transplantation.Semantic proximity Read ↗

Potential of autologous immunologic effector cells for bone marrow purging in patients with chronic myeloid leukemia.Semantic proximity Read ↗

Phenotypic and functional reconstitution of peripheral blood lymphocytes following T cell-depleted bone marrow transplantation from partially mismatched related donors.Semantic proximity Read ↗

Characterization of OKT3-initiated lymphokine-activated effectors expanded with interleukin 2 and tumor necrosis factor alpha.Semantic proximity Read ↗

Lymphokine-activated killer (LAK) cells modulate the effects of IL-2 on a T cell-mediated immune response.Semantic proximity Read ↗

Interleukin-2 activation of human bone marrow in long-term cultures: an effective strategy for purging and generation of anti-tumor cytotoxic effectors.Semantic proximity Read ↗

Effect of culture media on lymphokine-activated killer effector phenotype and lytic capacity.Semantic proximity Read ↗

Reconstitution of T-cell function after CD6-depleted allogeneic bone marrow transplantation.Semantic proximity Read ↗

Development of four donor-specific phenotypes in human long-term lymphokine-activated killer cell cultures.Semantic proximity Read ↗

Effects of escalating doses of recombinant human interleukin-2 in correcting functional T-cell defects following autologous bone marrow transplantation for lymphomas and solid tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.