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Article

Variable number of tandem repeat polymorphisms of DRD4: re-evaluation of selection hypothesis and analysis of association with schizophrenia.

European journal of human genetics : EJHG - 1 Jun 2009

Hattori Eiji, Nakajima Mizuho, Yamada Kazuo, Iwayama Yoshimi, Toyota Tomoko, Saitou Naruya, Yoshikawa Takeo

Abstract excerpt

Associations have been reported between the variable number of tandem repeat (VNTR) polymorphisms in the exon 3 of dopamine D4 receptor gene gene and multiple psychiatric illnesses/traits. We examined the distribution of VNTR alleles of different length in a Japanese cohort and found that, as reported earlier, the size of allele '7R' was much rarer (0.5%) in Japanese than in Caucasian populations (approximately...

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Source

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Identifiers

PMID: 19092778
DOI: 10.1038/ejhg.2008.247
PMCID: PMC2947105

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Variable number of tandem repeat polymorphisms of DRD4: re-evaluation of selection hypothesis and analysis of association with schizophrenia.PMID 19092778Read ↗

The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus.Semantic proximity Read ↗

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Evidence of positive selection acting at the human dopamine receptor D4 gene locus.Semantic proximity Read ↗

Genetic structure of the dopamine receptor D4 gene (DRD4) and lack of association with schizophrenia in Japanese patients.Semantic proximity Read ↗

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Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenics.Semantic proximity Read ↗

Schizophrenia is not associated with DRD4 48-base-pair-repeat length or individual alleles: results of a meta-analysis.Semantic proximity Read ↗

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