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Article

Ab-origin: an enhanced tool to identify the sourcing gene segments in germline for rearranged antibodies.

BMC bioinformatics - 12 Dec 2008

Wang Xiaojing, Wu Di, Zheng Siyuan, Sun Jing, Tao Lin, Li Yixue, Cao Zhiwei

Abstract excerpt

BACKGROUND: In the adaptive immune system, variable regions of immunoglobulin (IG) are encoded by random recombination of variable (V), diversity (D), and joining (J) gene segments in the germline. Partitioning the functional antibody sequences to their sourcing germline gene segments is vital not only for understanding antibody maturation but also for promoting the potential engineering of the therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19091020
DOI: 10.1186/1471-2105-9-S12-S20
PMCID: PMC2638160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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