Article
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes.
Nature communications - 25 May 2020
ElInati Elias, Zielinska Agata P, McCarthy Afshan, Kubikova Nada, Maciulyte Valdone, Mahadevaiah Shantha, Sangrithi Mahesh N, Ojarikre Obah, Wells Dagan, Niakan Kathy K, Schuh Melina, Turner James M A
Abstract excerpt
DNA double-strand breaks (DSBs) are toxic to mammalian cells. However, during meiosis, more than 200 DSBs are generated deliberately, to ensure reciprocal recombination and orderly segregation of homologous chromosomes. If left unrepaired, meiotic DSBs can cause aneuploidy in gametes and compromise viability in offspring. Oocytes in which DSBs persist are therefore eliminated by the DNA-damage checkpoint. Here we...
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