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Article

Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations.

The Journal of cell biology - 1 Feb 1994

Williams B D, Waterston R H

Abstract excerpt

By taking advantage of a lethal phenotype characteristic of Caenorhabditis elegans embryos that fail to move, we have identified 13 genes required for muscle assembly and function and discovered a new lethal class of alleles for three previously known muscle-affecting genes. By staining mutant embryos for myosin and actin we have recognized five distinct classes of genes: mutations in four genes disrupt the...

Topics

Actins
Animals
Antibodies
Caenorhabditis elegans
Chromosome Mapping
Female
Genes, Lethal
Genetic Complementation Test
Immunohistochemistry
Male
Muscles
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharynx

Phenotype

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Identifiers

PMID: 8106547
DOI: 10.1083/jcb.124.4.475
PMCID: PMC2119919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8106547-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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