Computer-based redesign of a beta sandwich protein suggests that extensive negative design is not required for de novo beta sheet design.

Abstract excerpt

The de novo design of globular beta sheet proteins remains largely an unsolved problem. It is unclear whether most designs are failing because the designed sequences do not have favorable energies in the target conformations or whether more emphasis should be placed on negative design, that is, explicitly identifying sequences that have poor energies when adopting undesired conformations. We tested whether we...

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