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Article

Redesigning the hydrophobic core of a model beta-sheet protein: destabilizing traps through a threading approach.

Proteins - 1 Dec 1999

Sorenson J M, Head-Gordon T

Abstract excerpt

An off-lattice 46-bead model of a small all-beta protein has been recently criticized for possessing too many traps and long-lived intermediates compared with the folding energy landscape predicted for real proteins and models using the principle of minimal frustration. Using a novel sequence design approach based on threading for finding beneficial mutations for destabilizing traps, we proposed three new...

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Identifiers

PMID: 10651274
DOI: 10.1002/(sici)1097-0134(19991201)37:4<582::aid-prot9>3.0.co;2-m

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Source receipt: pubmed, retrieved 7 Sept 2026.

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