Article
Oncologic trogocytosis of an original stromal cells induces chemoresistance of ovarian tumours.
PloS one - 1 Jan 2008
Rafii Arash, Mirshahi Pejman, Poupot Mary, Faussat Anne-Marie, Simon Anne, Ducros Elodie, Mery Eliane, Couderc Bettina, Lis Raphael, Capdet Jerome, Bergalet Julie, Querleu Denis, Dagonnet Francoise, Fournié Jean-Jacques, Marie Jean-Pierre, Pujade-Lauraine Eric, Favre Gilles, Soria Jeanine, Mirshahi Massoud
Abstract excerpt
BACKGROUND: The microenvironment plays a major role in the onset and progression of metastasis. Epithelial ovarian cancer (EOC) tends to metastasize to the peritoneal cavity where interactions within the microenvironment might lead to chemoresistance. Mesothelial cells are important actors of the peritoneal homeostasis; we determined their role in the acquisition of chemoresistance of ovarian tumours....
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