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Article

Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents.

PloS one - 1 Jan 2015

Pasdar Elham Alizadeh, Smits Michael, Stapelberg Michael, Bajzikova Martina, Stantic Marina, Goodwin Jacob, Yan Bing, Stursa Jan, Kovarova Jaromira, Sachaphibulkij Karishma, Bezawork-Geleta Ayenachew, Sobol Margaryta, Filimonenko Anatoly, Tomasetti Marco, Zobalova Renata, Hozak Pavel, Dong Lan-Feng, Neuzil Jiri

Abstract excerpt

Malignant mesothelioma (MM) is an aggressive type of tumour causing high mortality. One reason for this paradigm may be the existence of a subpopulation of tumour-initiating cells (TICs) that endow MM with drug resistance and recurrence. The objective of this study was to identify and characterise a TIC subpopulation in MM cells, using spheroid cultures, mesospheres, as a model of MM TICs. Mesospheres, typified...

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Source

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Identifiers

PMID: 25932953
DOI: 10.1371/journal.pone.0119549
PMCID: PMC4416766

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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