Article
A bacterial G protein-mediated response to replication arrest.
Molecular cell - 18 Feb 2005
Foti James J, Schienda Jaclyn, Sutera Vincent A, Lovett Susan T
Abstract excerpt
To define factors in E. coli promoting survival to replication fork stress, we isolated insertion mutants sensitive to replication inhibitors. One insertion caused partial loss of the universally conserved GTPase, obgE/yhbZ gene. Although obgE is essential for growth, our insertion allele supported viability until challenged with various replication inhibitors. A mutation designed to negate the GTPase activity of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.