Article
On combining triads and unrelated subjects data in candidate gene studies: an application to data on testicular cancer.
Human heredity - 1 Jan 2009
Hsu Li, Starr Jacqueline R, Zheng Yingye, Schwartz Stephen M
Abstract excerpt
Combining data collected from different sources is a cost-effective and time-efficient approach for enhancing the statistical efficiency in estimating weak-to-modest genetic effects or gene-gene or gene-environment interactions. However, combining data across studies becomes complicated when data are collected under different study designs, such as family-based and unrelated individual-based (e.g.,...
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