Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.

doi:10.1186/gb-2008-9-12-r171

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Article

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.

Genome biology - 1 Jan 2008

Neafsey Daniel E, Schaffner Stephen F, Volkman Sarah K, Park Daniel, Montgomery Philip, Milner Danny A, Lukens Amanda, Rosen David, Daniels Rachel, Houde Nathan, Cortese Joseph F, Tyndall Erin, Gates Casey, Stange-Thomann Nicole, Sarr Ousmane, Ndiaye Daouda, Ndir Omar, Mboup Soulyemane, Ferreira Marcelo U, Moraes Sandra do Lago, Dash Aditya P, Chitnis Chetan E, Wiegand Roger C, Hartl Daniel L, Birren Bruce W, Lander Eric S, Sabeti Pardis C, Wirth Dyann F

Abstract excerpt

BACKGROUND: The malaria parasite Plasmodium falciparum exhibits abundant genetic diversity, and this diversity is key to its success as a pathogen. Previous efforts to study genetic diversity in P. falciparum have begun to elucidate the demographic history of the species, as well as patterns of population structure and patterns of linkage disequilibrium within its genome. Such studies will be greatly enhanced by...

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PMID: 19077304
DOI: 10.1186/gb-2008-9-12-r171
PMCID: PMC2646275

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