Article
Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies.
BMC genetics - 13 Jul 2010
Orjuela-Sánchez Pamela, Karunaweera Nadira D, da Silva-Nunes Mônica, da Silva Natal S, Scopel Kézia K G, Gonçalves Raquel M, Amaratunga Chanaki, Sá Juliana M, Socheat Duong, Fairhust Rick M, Gunawardena Sharmini, Thavakodirasah Thuraisamy, Galapaththy Gawrie L N, Abeysinghe Rabindra, Kawamoto Fumihiko, Wirth Dyann F, Ferreira Marcelo U
Abstract excerpt
BACKGROUND: The ideal malaria parasite populations for initial mapping of genomic regions contributing to phenotypes such as drug resistance and virulence, through genome-wide association studies, are those with high genetic diversity, allowing for numerous informative markers, and rare meiotic recombination, allowing for strong linkage disequilibrium (LD) between markers and phenotype-determining loci. However,...
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