Article
Marker-assisted dissection of genetic influences on motor and neuroendocrine sensitization to cocaine in rats.
Genes, brain, and behavior - 1 Apr 2009
Vendruscolo L F, Vendruscolo J C M, Terenina E, Ramos A, Takahashi R N, Mormède P
Abstract excerpt
This study investigated genetic influences on behavioral and neuroendocrine responses to cocaine sensitization. We used male and female rats of the inbred strains Lewis (LEW) and spontaneously hypertensive rats (SHR), which display genetic differences in stress-related responses. The influence of two quantitative trait loci (QTL; Ofil1 and Ofil2 on chromosomes 4 and 7), which modulate stress reactivity in rats,...
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