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Article

Genetic variation in vulnerability to the behavioral effects of neonatal hippocampal damage in rats.

Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 1995

Lipska B K, Weinberger D R

Abstract excerpt

We explored how two independent variables, one genetic (i.e., specific rat strains) and another environmental (i.e., a developmental excitotoxic hippocampal lesion), contribute to phenotypic variation. Sprague-Dawley (SD), Fischer 344 (F344), and Lewis rats underwent two grades of neonatal excitotoxic damage: small and large ventral hippocampal (SVH and LVH) lesions. Locomotion was tested before puberty...

Topics

Analysis of Variance
Animals
Animals, Newborn
Behavior, Animal
Genetic Variation
Hippocampus
Models, Psychological
Motor Activity
Rats
Rats, Inbred F344
Rats, Inbred Lew

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Sprague-Dawley

Species Specificity

Stress, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 7568041
DOI: 10.1073/pnas.92.19.8906
PMCID: PMC41076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7568041-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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