Article
Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.
Human molecular genetics - 1 Oct 2002
Vasseur Francis, Helbecque Nicole, Dina Christian, Lobbens Stéphane, Delannoy Valérie, Gaget Stéphane, Boutin Philippe, Vaxillaire Martine, Leprêtre Frédéric, Dupont Sophie, Hara Kazuo, Clément Karine, Bihain Bernard, Kadowaki Takashi, Froguel Philippe
Abstract excerpt
Adiponectin (ACRP30), an adipocyte-secreted protein encoded by the APM1 gene, is known to modulate insulin sensitivity and glucose homeostasis, those effects protecting obese mice from diabetes. Plasma adiponectin levels correlate well with insulin sensitivity in humans, and are decreased in both type 2 diabetes (T2D) and obesity. We screened for single-nucleotide polymorphisms (SNPs) the APM1 gene coding and 5'...
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