Article
Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians.
Diabetes - 1 Feb 2006
Heid Iris M, Wagner Stefanie A, Gohlke Henning, Iglseder Bernhard, Mueller Jakob C, Cip Paula, Ladurner Günther, Reiter Raphael, Stadlmayr Andreas, Mackevics Vitolds, Illig Thomas, Kronenberg Florian, Paulweber Bernhard
Abstract excerpt
The associations of the adiponectin (APM1) gene with parameters of the metabolic syndrome are inconsistent. We performed a systematic investigation based on fine-mapped single nucleotide polymorphisms (SNPs) highlighting the genetic architecture and their role in modulating adiponectin plasma concentrations in a particularly healthy population of 1,727 Caucasians avoiding secondary effects from disease processes....
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