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Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma

15 Dec 2008

Abstract excerpt

The recent identification of cancer stem cells (CSCs) in multiple human cancers provides a new inroad to understanding tumorigenesis at the cellular level. CSCs are defined by their characteristics of self-renewal, multipotentiality, and tumor initiation upon transplantation. By testing for these defining characteristics, we provide evidence for the existence of CSCs in a transgenic mouse model of glioma,...

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PMID: 19074870
DOI: 10.1158/0008-5472.can-08-0786

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