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Article

Menin Promotes the Wnt Signaling Pathway in Pancreatic Endocrine Cells

1 Dec 2008

Abstract excerpt

Menin is a tumor suppressor protein mutated in patients with multiple endocrine neoplasia type 1. We show that menin is essential for canonical Wnt/beta-catenin signaling in cultured rodent islet tumor cells. In these cells, overexpression of menin significantly enhances TCF gene assay reporter activity in response to beta-catenin activation. Contrastingly, inhibition of menin expression with Men1 siRNA decreases...

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PMID: 19074834
DOI: 10.1158/1541-7786.mcr-07-2206

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