Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Menin links estrogen receptor activation to histone H3K4 trimethylation.

Cancer research - 1 May 2006

Dreijerink Koen M A, Mulder Klaas W, Winkler G Sebastiaan, Höppener Jo W M, Lips Cornelis J M, Timmers H Th Marc

Abstract excerpt

The product of the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor gene, menin, is an integral component of MLL1/MLL2 histone methyltransferase complexes specific for Lys4 of histone H3 (H3K4). We show that menin is a transcriptional coactivator of the nuclear receptors for estrogen and vitamin D. Activation of the endogenous estrogen-responsive TFF1 (pS2) gene results in promoter recruitment of menin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to COS Cells
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Histones

Share to Proto-Oncogene Proteins

Share to Transcriptional Activation

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 16651450
DOI: 10.1158/0008-5472.CAN-05-4461

Genes

MEN1
TFF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Menin links estrogen receptor activation to histone H3K4 trimethylation.PMID 16651450Read ↗

Twenty years of menin: emerging opportunities for restoration of transcriptional regulation in MEN1Semantic proximity Read ↗

Menin regulates endocrine diseases by controlling histone modification and gene transcription.Semantic proximity Read ↗

Multiple endocrine neoplasia type 1: a chromatin writer's block.Semantic proximity Read ↗

Menin mediates epigenetic regulation via histone H3 lysine 9 methylation.Semantic proximity Read ↗

Menin, Histone H3 Methyltransferases, and Regulation of Cell Proliferation: Current Knowledge and PerspectiveSemantic proximity Read ↗

Epigenetic regulation by the menin pathwaySemantic proximity Read ↗

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.Semantic proximity Read ↗

Menin in CancerSemantic proximity Read ↗

Menin: from molecular insights to clinical impactSemantic proximity Read ↗

Menin: a scaffold protein that controls gene expression and cell signaling.Semantic proximity Read ↗

Menin Molecular Interactions: Insights into Normal Functions and TumorigenesisSemantic proximity Read ↗

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.