The Tumor Suppressor Protein Menin Inhibits AKT Activation by Regulating Its Cellular Localization

Abstract excerpt

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder associated mainly with tumors of multiple endocrine organs. Mutations in the MEN1 gene that encodes for the menin protein are the predominant cause for hereditary MEN1 syndrome. Though menin is a tumor suppressor, its molecular mechanism of action has not been defined. Here, we report that menin interacts with AKT1 in vitro and in vivo....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neuroblastoma Research and Treatments
• Share to Neuroendocrine Tumor Research Advances
• Share to PI3K/AKT/mTOR signaling in cancer