Article
Menin mediates epigenetic regulation via histone H3 lysine 9 methylation.
Cell death & disease - 11 Apr 2013
Yang Y-J, Song T-Y, Park J, Lee J, Lim J, Jang H, Kim Y-N, Yang J-H, Song Y, Choi A, Lee H Y, Jo C H, Han J W, Kim S-T, Youn H-D, Cho E-J
Abstract excerpt
Menin, encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, is a tumor suppressor that leads to multiple endocrine tumors upon loss of its function. Menin functions as a transcriptional activator by tethering MLL complex to mediate histone H3 K4 methylation. It also functions as a repressor. However, the molecular mechanism of how menin contributes to the opposite outcome in gene expression is largely...
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