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Activation of bovine somatic cell nuclear transfer embryos by PLCZ cRNA injection

12 Dec 2008

Abstract excerpt

The production of cloned animals by the transfer of a differentiated somatic cell into an enucleated oocyte circumvents fertilization. During fertilization, the sperm delivers a sperm-specific phospholipase C (PLCZ) that is responsible for triggering Ca(2)(+) oscillations and oocyte activation. During bovine somatic cell nuclear transfer (SCNT), oocyte activation is artificially achieved by combined chemical...

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PMID: 19074500
DOI: 10.1530/rep-08-0419

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