Dorothy Hodgkin lecture 2024: Insulin regulation of mitochondrial biogenesis and function—Impact of dysregulation of mitochondrial function in diabetes and its complications

Abstract excerpt

Skeletal muscle atrophy was a characteristic of type 1 diabetes (T1DM) prior to insulin discovery and replacement. Indirect calorimetry during the post-absorptive state demonstrated that increased fuel oxidation during transient insulin deprivation in T1DM caused depletion of energy stores. Further, insulin has a critical role in preserving muscle mitochondrial content and function by enhancing mitochondrial...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adipose Tissue and Metabolism
• Share to Diet and metabolism studies
• Share to Mitochondrial Function and Pathology