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Article

Myocardial glucose uptake in patients with the m.3243A > G mutation in mitochondrial DNA.

Journal of inherited metabolic disease - 1 Jan 2016

Lindroos Markus M, Pärkkä Jussi P, Taittonen Markku T, Iozzo Patricia, Kärppä Mikko, Hassinen Ilmo E, Knuuti Juhani, Nuutila Pirjo, Majamaa Kari

Abstract excerpt

Mitochondrial mutations impair glucose oxidation and increase glucose uptake in cell cultures and lead to cardiomyopathy in patients. Here we characterize cardiac glucose uptake in 14 patients with the m.3243A > G mutation in mitochondrial DNA. The 14 patients with m.3243A > G and 13 controls were similar in age, physical activity and body mass index. Ten patients had diabetes. Left ventricular glucose uptake per...

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Identifiers

PMID: 26112752
DOI: 10.1007/s10545-015-9865-1

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