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Mitochondrial heteroplasmy-phenotype correlation and response to glucose lowering therapy in subjects with m.3243A>G mutations.

Diabetes & metabolism - 1 Sept 2025

Ng N, Sanchez-Lechuga B, McCarrick C J, Mangan C, Burke M, Ioana J A, Gavin C, O'Byrne R, O'Byrne J J, Byrne M M

Abstract excerpt

INTRODUCTION: There is a paucity of evidence to guide pharmacological treatment for mitochondrial diabetes. Metformin is generally contraindicated due to the high risk of lactic acidosis, Sulphonylurea (SU) therapy has been used as 1st line therapy but most progress to insulin. The aim of this study is to investigate the glucose-insulin secretory response to oral glucose, the response to glucose lowering therapy,...

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PMID: 40541739
DOI: 10.1016/j.diabet.2025.101678

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