Article
A BRCA1 mutation is not associated with increased indicators of oxidative stress.
Clinical breast cancer - 1 Dec 2008
Kotsopoulos Joanne, Shen HongLei, Rao A Venketeshwer, Poll Aletta, Ainsworth Peter, Fleshner Neil, Narod Steven A
Abstract excerpt
BACKGROUND: Several functions have been attributed to the BRCA1 protein. A recent study suggests that BRCA1 is involved in the cellular antioxidant response by inducing the expression of genes involved in the antioxidant defense system and thus conferring resistance to oxidative stress. It is possible that individuals with a BRCA1 mutation might be susceptible to the effects of oxidative stress. The aim of this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.