Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1.

doi:10.1136/jmg.38.12.824

Article

Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1.

Journal of medical genetics - 1 Dec 2001

Eng C, Brody L C, Wagner T M, Devilee P, Vijg J, Szabo C, Tavtigian S V, Nathanson K L, Ostrander E, Frank T S

Abstract excerpt

While sequence analysis is considered by many to be the most sensitive method of detecting unknown mutations in large genes such as BRCA1, most published estimates of the prevalence of mutations in this gene have been derived from studies that have used other methods of gene analysis. In order to determine the relative sensitivity of techniques that are widely used in research on BRCA1, a set of blinded samples...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1.

Abstract excerpt

Topics

Related research