Article
Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion.
Biochemical and biophysical research communications - 30 Jan 2009
Liu Rujuan, Xu Hang, Wei Zhiyi, Wang Yanli, Lin Yajing, Gong Weimin
Abstract excerpt
It is well known that motion of LID and NMP-binding (NMP(bind)) domains in adenylate kinase (AK) is important in ligand binding and catalysis. However, the nature of such domain motions is poorly characterized. One of the critical hinge regions is hinge IV, which connects the CORE and LID domains...
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