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Article

An optical assay of the transport activity of ClC-7.

Scientific reports - 1 Jan 2013

Zanardi Ilaria, Zifarelli Giovanni, Pusch Michael

Abstract excerpt

Osteoporosis, characterized by excessive osteoclast mediated bone resorption, affects millions of people worldwide representing a major public health problem. ClC-7 is a chloride-proton exchanger localized in lysosomes and in the resorption lacuna in osteoclasts where it is essential for bone resorption. Thus, drugs targeted at ClC-7 have been proposed for ameliorating osteoporosis. However, functional assays...

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Identifiers

PMID: 23390581
DOI: 10.1038/srep01231
PMCID: PMC3565172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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