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Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass

1 May 2019

Abstract excerpt

Bone mineral density (BMD) is a strong predictor of osteoporotic fracture.It is also one of the most heritable disease-associated quantitative traits.As a result, there has been considerable effort focused on dissecting its genetic basis.Here, we performed a genome-wide association study (GWAS) in a panel of inbred strains to identify associations influencing BMD.This analysis identified a significant (P = 3.1 x...

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PMID: 31042701
DOI: 10.1371/journal.pgen.1008123

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