Article
Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density.
Human molecular genetics - 1 Apr 2012
Xiao Su-Mei, Kung Annie Wai Chee, Gao Yi, Lau Kam-Shing, Ma Alvin, Zhang Zhen-Lin, Liu Jian-Min, Xia Wiebo, He Jin-Wei, Zhao Lin, Nie Min, Fu Wei-Zhen, Zhang Min-Jia, Sun Jing, Kwan Johnny S H, Tso Gloria Hoi Wan, Dai Zhi-Jie, Cheung Ching-Lung, Bow Cora H, Leung Anskar Yu Hung, Tan Kathryn Choon Beng, Sham Pak Chung
Abstract excerpt
Our previous genome-wide association study (GWAS) in a Hong Kong Southern Chinese population with extreme bone mineral density (BMD) scores revealed suggestive association with MPP7, which ranked second after JAG1 as a candidate gene for BMD. To follow-up this suggestive signal, we replicated the top single-nucleotide polymorphism rs4317882 of MPP7 in three additional independent Asian-descent samples (n= 2684)....
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