Article
Preliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine.
Journal of affective disorders - 1 Jul 2009
Cooper-Kazaz Rena, van der Deure Wendy M, Medici Marco, Visser Theo J, Alkelai Ana, Glaser Benjamin, Peeters Robin P, Lerer Bernard
Abstract excerpt
BACKGROUND: Triiodothyronine (T3) is used to potentiate the clinical effect of antidepressant drugs. Inter-individual differences in efficacy may be related to genetically-based variability in thyroid function. METHODS: DNA was obtained from 64 patients treated with sertraline plus T3 (SERT-T3, N=35) or plus placebo (SERT-PLB, N=29), for 8 weeks. Antidepressant efficacy was rated with the 21 item Hamilton Rating...
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