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Article

TAZ Promotes PC2 Degradation through a SCF <sup>β-Trcp</sup> E3 Ligase Complex

16 Jul 2007

Abstract excerpt

Studies of a TAZ knockout mouse reveal a novel function of the transcriptional regulator TAZ, that is, as a binding partner of the F-box protein beta-Trcp. TAZ-/- mice develop polycystic kidney disease (PKD) and emphysema. The calcium-permeable cation channel protein polycystin 2 (PC2) is overexpressed in kidneys of TAZ-/- mice as a result of decreased degradation via an SCF(beta-Trcp) E3 ubiquitin ligase...

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Identifiers

PMID: 17636028
DOI: 10.1128/mcb.00254-07

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