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Article

Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells.

Molecular cancer - 5 Dec 2008

Zaytseva Yekaterina Y, Wang Xin, Southard R Chase, Wallis Natalie K, Kilgore Michael W

Abstract excerpt

BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily and is highly expressed in many human tumors including breast cancer. PPARgamma has been identified as a potential target for breast cancer therapy based on the fact that its activation by synthetic ligands affects the differentiation, proliferation, and apoptosis of cancer cells....

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Share to Apoptosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 19061500
DOI: 10.1186/1476-4598-7-90
PMCID: PMC2614423

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MAZ

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