Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line.

Oncogene - 21 Aug 2003

Pignatelli Miguel, Cocca Claudia, Santos Angel, Perez-Castillo Ana

Abstract excerpt

BRCA1 has been linked to the genetic susceptibility of a majority of familial breast and ovarian cancers. Several lines of evidence indicate that BRCA1 is a tumor suppressor and its expression is downregulated in sporadic breast and ovarian cancer cases. Therefore, the identification of genes involved in the regulation of BRCA1 gene expression might lead to new insights into the pathogenesis and treatment of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to Breast Neoplasms
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Receptors, Cytoplasmic and Nuclear

Share to Rosiglitazone

Share to Thiazoles

Share to Thiazolidinediones

Share to Transcription Factors

Source

Identifiers

PMID: 12934104
DOI: 10.1038/sj.onc.1206824

Genes

BRCA1
DR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line.PMID 12934104Read ↗

Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells.Semantic proximity Read ↗

The PPARgamma antagonist T0070907 suppresses breast cancer cell proliferation and motility via both PPARgamma-dependent and -independent mechanisms.Semantic proximity Read ↗

Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation.Semantic proximity Read ↗

Anticancer activities of PPARγ in breast cancer are context-dependent.Semantic proximity Read ↗

Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progressionSemantic proximity Read ↗

The localisation and reduction of nuclear staining of PPARγ and PGC-1 in human breast cancerSemantic proximity Read ↗

Joint effect of peroxisome proliferator-activated receptor γ genetic polymorphisms and estrogen-related risk factors on breast cancer risk: results from a case-control study in Taiwan.Semantic proximity Read ↗

Vitamin D receptor, Retinoid X receptor and peroxisome proliferator-activated receptor γ are overexpressed in BRCA1 mutated breast cancer and predict prognosis.Semantic proximity Read ↗

Opposing roles for mammary epithelial-specific PPARγ signaling and activation during breast tumour progressionSemantic proximity Read ↗

Mutational analysis of the peroxisome proliferator-activated receptor gamma gene in human malignancies.Semantic proximity Read ↗

Identification of a truncated alternative splicing variant of human PPARgamma1 that exhibits dominant negative activity.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.