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The Biological Significance and Implications of Planar Cell Polarity for Nephrology

26 Feb 2021

Abstract excerpt

The orientation of cells in two-dimensional and three-dimensional space underpins how the kidney develops and responds to disease. The process by which cells orientate themselves within the plane of a tissue is termed planar cell polarity. In this Review, we discuss how planar cell polarity and the proteins that underpin it govern kidney organogenesis and pathology. The importance of planar cell polarity and its...

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PMID: 33716764
DOI: 10.3389/fphys.2021.599529

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