The Neurotrophins and Neuropoietic Cytokines: Two Families of Growth Factors Acting on Neural and Hematopoietic Cells

Abstract excerpt

Recent progress has revealed similarities between the receptors and signaling systems used by neurotrophic factors as compared to other growth factors and cytokines. The neurotrophins use a family of receptor tyrosine kinases known as the Trk receptors, whereas ciliary neurotrophic factor (CNTF) uses a "cytokine receptor" system that shares receptor components with a number of distantly related cytokines. We have...

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