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Article

Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles.

PLoS pathogens - 1 Dec 2008

Thuong Nguyen Thuy Thuong, Dunstan Sarah J, Chau Tran Thi Hong, Thorsson Vesteinn, Simmons Cameron P, Quyen Nguyen Than Ha, Thwaites Guy E, Thi Ngoc Lan Nguyen, Hibberd Martin, Teo Yik Y, Seielstad Mark, Aderem Alan, Farrar Jeremy J, Hawn Thomas R

Abstract excerpt

Although host genetics influences susceptibility to tuberculosis (TB), few genes determining disease outcome have been identified. We hypothesized that macrophages from individuals with different clinical manifestations of Mycobacterium tuberculosis (Mtb) infection would have distinct gene expression profiles and that polymorphisms in these genes may also be associated with susceptibility to TB. We measured gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19057661
DOI: 10.1371/journal.ppat.1000229
PMCID: PMC2585058

Genes

CCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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