Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced S-nitrosylation of TGFβ1 elevates its binding affinity toward the receptor and promotes fibrogenic signaling in the breast.

The Journal of biological chemistry - 1 Dec 2024

Letson Joshua, Ren Gang, Zheng Xunzhen, Sweef Osama, Corcino Yalitza Lopes, Furuta Saori

Abstract excerpt

Transforming Growth Factor β (TGFβ) is a pleiotropic cytokine closely linked to tumors. Previously, we pharmacologically inhibited basal nitric oxide (NO) production in healthy mammary glands and found that this induced precancerous progression accompanied by upregulation of TGFβ and desmoplasia. In the present study, we tested whether NO directly S-nitrosylates (forms an NO-adduct at a cysteine residue) TGFβ for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cysteine

Share to Nitric Oxide

Share to Protein Binding

Share to Protein Multimerization

Share to Receptors, Transforming Growth Factor beta

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 39571651
DOI: 10.1016/j.jbc.2024.108011
PMCID: PMC11699740

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Reduced S-nitrosylation of TGFβ1 elevates its binding affinity toward the receptor and promotes fibrogenic signaling in the breast.PMID 39571651Read ↗

Computational Structural Biology of S-nitrosylation of Cancer TargetsSemantic proximity Read ↗

A substrate trapping approach identifies proteins regulated by reversible S-nitrosylation.Semantic proximity Read ↗

S-Nitrosylation of the epidermal growth factor receptor: a regulatory mechanism of receptor tyrosine kinase activity.Semantic proximity Read ↗

Protein-S-Nitrosylation of Human Cytomegalovirus pp65 Reduces its Ability to Undermine cGASSemantic proximity Read ↗

S-nitrosylated COX-2 is a microenvironment-regulated breast cancer cell biomarker of mesenchymal phenotypes.Semantic proximity Read ↗

GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylationSemantic proximity Read ↗

Inhibition of Epithelial-to-Mesenchymal Transition (EMT) in Cancer by Nitric Oxide: Pivotal Roles of Nitrosylation of NF-κB, YY1 and SnailSemantic proximity Read ↗

Nitric oxide S-nitrosylates CSF1R to augment the action of CSF1R inhibition against castration resistant prostate cancerSemantic proximity Read ↗

S-nitrosylation of CSF1 receptor increases the efficacy of CSF1R blockage against Prostate cancerSemantic proximity Read ↗

Regulation of HIF-1alpha stability through S-nitrosylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.