Article
Evaluation of channel function after alteration of amino acid residues at the pore center of KCNQ1 channel.
Biochemical and biophysical research communications - 16 Jan 2009
Ikrar Taruna, Hanawa Haruo, Watanabe Hiroshi, Aizawa Yoshiyasu, Ramadan Mahmoud M, Chinushi Masaomi, Horie Minoru, Aizawa Yoshifusa
Abstract excerpt
The effect of the electrical charge or the size of the amino acid residue at the pore center of a slowly activation component of the delayed rectifier potassium channel: KCNQ1 was studied. K(+) currents were measured after transfection of one of four KCNQ1 mutants: substituting Isoleucine with Lysine, Glutamate, Valine or Glycine and then transfected in COS-7 cells. Both the negatively- and positive charged...
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