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Article

Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy.

The Journal of biological chemistry - 5 May 2000

Schwake M, Pusch M, Kharkovets T, Jentsch T J

Abstract excerpt

Mutations in either KCNQ2 or KCNQ3 underlie benign familial neonatal convulsions (BFNC), an inherited epilepsy. The corresponding proteins are co-expressed in broad regions of the brain and associate to heteromeric K(+) channels. These channels mediate M-type currents that regulate neuronal excitability. We investigated the basis for the increase in currents seen after co-expressing these subunits in Xenopus...

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Source

Identifiers

PMID: 10788442
DOI: 10.1074/jbc.275.18.13343

Genes

KCNQ2
KCNQ3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy.PMID 10788442Read ↗

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