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Article

A double-point mutation in the selectivity filter site of the KCNQ1 potassium channel results in a severe phenotype, LQT1, of long QT syndrome.

Journal of cardiovascular electrophysiology - 1 May 2008

Ikrar Taruna, Hanawa Haruo, Watanabe Hiroshi, Okada Shinsuke, Aizawa Yoshiyasu, Ramadan Mahmoud M, Komura Satoru, Yamashita Fumio, Chinushi Masaomi, Aizawa Yoshifusa

Abstract excerpt

INTRODUCTION: Slowly activating delayed-rectifier potassium currents in the heart are produced by a complex protein with alpha and beta subunits composed of the potassium voltage-gated channel KQT-like subfamily, member 1 (KCNQ1) and the potassium voltage-gated channel Isk-related family, member 1 (KCNE1), respectively. Mutations in KCNQ1 underlie the most common type of hereditary long QT syndrome (LQTS). Like...

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Share to KCNQ1 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18266681
DOI: 10.1111/j.1540-8167.2007.01076.x

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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