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Article

Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples.

The Journal of clinical investigation - 1 Mar 2003

Wang Yi-Ching, Lu Yung-Pin, Tseng Ruo-Chia, Lin Ruo-Kai, Chang Jer-Wei, Chen Jung-Ta, Shih Chuen-Ming, Chen Chih-Yi

Abstract excerpt

We performed a genetic and epigenetic study of the hMLH1 and hMSH2 mismatch repair genes in resected primary tumors from 77 non-small cell lung cancer (NSCLC) patients. The molecular alterations examined included the loss of mRNA and protein expression as well as promoter methylation, and the all...

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Identifiers

PMID: 12639995
DOI: 10.1172/JCI15475
PMCID: PMC153761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12639995-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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